文章摘要
张利红.雄烯二酮和甲基睾酮诱导雌性日本鳗鲡性腺发育的反馈调节作用[J].水产学报,2000,24(5):
雄烯二酮和甲基睾酮诱导雌性日本鳗鲡性腺发育的反馈调节作用
The feedback effects of 4-androstene-3, 17-dine and 17A-methy-l testosterone on gonadal development in the female Anguilla japonica
投稿时间:2014-04-16  修订日期:2014-04-16
DOI:
中文关键词: 日本鳗鲡 性腺发育 反馈调节 雄烯二酮 甲基睾酮
英文关键词: Anguilla japonica  gonadal development  androgen  feedback effect
基金项目:国家自然科学基金项目39790101 号和1996 年度高校博士点专项科研资金
作者单位地址
张利红 中山大学生命科学学院 中山大学生命科学学院
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中文摘要:
      采用间隔15d 多次埋植雄激素雄烯二酮( 4- androstene- 3, 17- dine, ADSD) 或甲基睾酮( 17A-methy-l testosterone, MT) 诱导雌性日本鳗鲡( Anguilla japonica) 性腺发育成熟; 并着重研究埋植雄激素后, 雌鳗血清 中促性腺激素( GtH) 及脑和垂体中哺乳类促性腺激素释放激素( mGnRH) 含量的动态变化。一次或多次埋 植ADSD 后, 1~ 5d 的血清GtH 含量上升, 然后下降; 并且, 血清GtH 含量上升的幅度随埋植次数的增加而 增加; 对于MT 处理组, 只在埋植7 次后第15 天测得血清GtH 水平显著高于对照组, 但仍显著低于ADSD 处理组。这表明埋植ADSD 和MT 可促进GtH 的分泌, 但两者促进GtH 分泌的作用存在显著差异。埋植 ADSD 1d 后, 脑和垂体中mGnRH 含量明显增加, 第2 天后和对照组无明显差别, 表明ADSD 促进了mGnRH 的合成, 并可能有一定程度的释放。研究表明雄激素对性腺未发育成熟的雌性日本鳗鲡在脑和垂体两个 水平存在正反馈调节作用。
英文摘要:
      The effect s of 4-androstene-3, 17-dine ( ADSD) and 17A-methy-l testosterone ( MT) via implantation on maturat ion of the female silver eel, Anguilla japonica and their kinetic effects on serum GtH levels, brain and pituitary GnRH levels were studied. Serum GtH levels increased during the period of 1- 5 days after implantation of ADSD, and the responses elevated w ith increasing times of implantation of ADSD. Implantation of MT, however, did not increase serum GtH levels significantly, except on the 15th day after 7 times of implantation. These results indicated that implantation of ADSD and MT stimulated the secretion of GtH, and there was a difference in effect between ADSD and MT. A single ADSD implantation significantly increased mGnRH contents in the brain and pituitary one day after treatment, but two days later, mGnRH contents in the brain and pituitary returned to the levels of the controls, indicating that implantation of ADSD stimulated the mGnRH synthesis and secretion. Thus, androgen have positive feedback ef fects at the brain and pituitary level to st imulate gonadal development in the female silver eel.
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