文章摘要
李文笙,王 滨.鱼类生长抑素调控垂体生长激素分泌的作用机制[J].水产学报,2013,37(12):1863~1872
鱼类生长抑素调控垂体生长激素分泌的作用机制
Mechanisms of actions of somatostatin on the regulation of pituitary growth hormone release in fish
投稿时间:2013-06-18  修订日期:2013-09-22
DOI:DOI:10.3724/SP.J.1231.2014.48776
中文关键词: 鱼类  生长抑素  生长抑素受体  生长激素  信号转导
英文关键词: fish  somatostatin  somatostatin receptors  growth hormone  signal transduction
基金项目:现代农业产业技术体系专项(CARS-49);国家自然科学基金项目(31272639)
作者单位
李文笙 中山大学生命科学学院,有害生物控制与资源利用国家重点实验室,广东省水生经济动物良种繁育重点实验室 
王 滨 中山大学生命科学学院,有害生物控制与资源利用国家重点实验室,广东省水生经济动物良种繁育重点实验室 
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中文摘要:
      生长抑素是一个多基因、多功能的家族。通过其受体的介导参与机体的生长、发育、代谢、生殖以及免疫等生理过程。本文简要概括鱼类生长抑素及其受体的研究进展,重点对生长抑素调控垂体生长激素分泌的信号转导机制进行讨论,旨在加深对鱼类生长抑素作用机制的认识和了解。迄今,在鱼类中已经鉴定出6种生长抑素基因和4种生长抑素受体。由于存在多种生长抑素基因以及不同的加工过程,一种鱼可能产生多种形式的生长抑素多肽。鱼类进化过程中存在基因组复制,导致一种受体又有多种亚型。鱼类生长抑素调控垂体生长激素分泌的作用机制主要源自金鱼中的研究,结果表明,cAMP通路、钙离子通道以及PKC通路可能参与了金鱼生长抑素抑制垂体生长激素分泌的过程。生长抑素调控垂体生长激素分泌的作用机制是一个复杂的网络结构,多种信号通路参与其中;不同物种间的作用机制不尽相同。鱼类生长抑素基因、受体及其调控垂体生长激素分泌的作用机制仍有待进一步研究。
英文摘要:
      Somatostatin is a multifunctional tetradecapeptide which is involved in growth,development,metabolism and reproductive processes,via the specific seven α helical transmembrane G-protein-coupled receptors(GPCRs).This review briefly summarizes the progress of research on somatostatin and its receptors,with special emphasis on the intracellular signaling mechanisms mediating somatostatin actions on the regulation of pituitary growth hormone release in fish.To date,six somatostatin genes and four somatostatin receptors have been characterized in fish.The diversity of the somatostatin peptide family is due to the existence of multiple somatostatin genes as well as the tissue-specific differential processing of preprosomatostatin.The subtypes of somatostatin receptors are complex due to the polyploidization that occurred during fish lineage evolution.Information on the mechanisms of somatostatin suppression of GH secretion in teleosts is mainly derived from studies in goldfish,which indicates that cAMP formation,Ca2+ mobilization,and PKC activation may be involved in the mechanism through which somatostatin regulates GH secretion.However,the intricate web of intracellular signals is still far from being fully understood.In addition,species-specific differences in the mechanisms of GH release do exist in diverse models.The somatostatin genes,receptors and the mechanism of actions of somatostatin on pituitary GH release await further studies in teleosts.
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