文章摘要
脂源性外泌体的功能及其在水生动物中的研究进展
The function of adipose-derived exosomes and research progess in aquatic animals
投稿时间:2019-09-09  修订日期:2019-09-29
DOI:
中文关键词: 外泌体  功能  代谢紊乱  调控机制  研究进展
英文关键词: Exosomes  Function  Metabolic disorders  Regulatory mechanism  Research progress
基金项目:国家自然科学基金(31402311;31872581);NSFC-河南联合基金(U1704109);河南省重点科技攻关项目(国家科技合作领域)(182102410031)
作者单位E-mail
卢荣华 河南师范大学 421058146@qq.com 
吉红 西北农林科技大学 动物科技学院  
聂国兴 河南师范大学 niegx@htu.cn 
摘要点击次数: 55
全文下载次数: 0
中文摘要:
      外泌体是一种由多种细胞分泌的30-150 nm的小囊泡,其通过转运蛋白质,脂质、mRNAs和miRNAs等的方式影响或改变受体细胞的行为,已被证明是细胞间通讯的一种新模式。研究发现外泌体参与了脂肪合成及肥胖、肝脏脂肪变性、胰岛素抵抗、免疫调节、炎症反应、肿瘤发生、血管以及神经生成和成骨等过程。本文主要阐述了外泌体的形成与生物学特性、分离及鉴定的方法,重点阐述了脂肪来源的外泌体在机体生理及病理过程中的潜在作用,并概述了水产动物中外泌体的研究进展,以期为脂肪代谢及有关疾病的病理机制与潜在干预靶标的研究提供新的思路和途径,也为更多地了解外泌体可能在鱼类糖脂代谢紊乱中的作用提供基础理论知识。
英文摘要:
      Exosomes, a 30-150 nm vesicle, is secreted by a variety of cells, which influences or changes the behavior of recipient cells by transferring proteins, lipids, mRNAs and miRNAs, etc., and has been proved to be a new mode of intercellular communication. Exosomes have been found to be involved in the processes of fat synthesis and obesity, liver steatosis, insulin resistance, immune regulation, inflammatory response, tumorigenesis, vascular and neurogenesis, and osteogenesis. This article mainly expounds the formation and biological characteristics of exosomes, separation and identification method of exosomes. Moreover, it expounds the potential functions of adipose-derived exosome in the physiological and pathological process, and an overview of the research progress of exosomes in aquatic animals. It will provide new approach and way in pathological mechanisms of lipid metabolism, lipid metabolism related diseases and potential intervention target. Also, it will provide basic theoretical knowledge to know the role of exosome in glucose and lipid metabolism disturbance of fish.
HTML     下载PDF阅读器
关闭

手机扫一扫看